It is the large red gland located in the upper right portion of the abdomen, just beneath the diaphragm. Its main functions include storage and filtration of blood; secretion of bile, conversion of sugars into glycogen.The synthesis and breakdown of fats and the temporary storage of fatty acids. Liver is the most important organ of the body. It all depends how we live as our eating habits has been changed that’s the reason we find that liver problems has raised globally like liver cancer, bile duct diseases and many more. Liver is responsible for the more than 150 functions. In today’s world dangerous air pollution, pharmaceutical, bacteria and fungi which assault our liver daily so that means liver has to work very hard. One of the every 100 individual suffering from liver diseases and waiting for the liver transplants but there are decreased number of donors. Liver diseases are caused by a variety of factors and affecting everyone infants to older adults.

Hormonal balance – The liver helps maintain the proper level of hormones and is a key organ in regulating the hormone insulin for efficient food metabolism. The liver converts the thyroid hormone thyroxin (T4) into its more active form (T3).

Digestion and fat regulation – The liver is responsible for the production of bile that aids in the digestion of fats and fat-soluble vitamins. Bile is used to emulsify fats and fat-soluble vitamins (A, D, E, and K) for proper digestive absorption. The liver also removes some fat-soluble toxins from the body by first dissolving them in bile salts, and then excreting them in feces. The liver also controls the production of cholesterol and triglycerides (blood fats).

Following are the numbers of diseases can affect the liver:

  1. Primary Biliary cirrhosis.
  2. Chronic and acute hepatitis.
  3. Cirrhosis.
  4. Varicel bleeding.
  5. Viral hepatitis.
  6. Obesity.
  7. Alcohol.
  8. Genetics.
  9. Auto immune disorders.
  10. Drugs and toxins.
  11. Cancer.


It is happens when liver fails to filter the blood which leads to deposition of the sluggish and becomes overloaded. Liver failure can be either acute or chronic.

Acute Liver Failure

Acute liver failure happens very fast. In this type of failure loss of liver functions occurs within days. Acute liver failure happens suddenly without any previous symptoms. Causes of acute liver failure include drug overdose.

Chronic Liver Failure

Chronic liver failure happens slower. It takes months or even years before exhibiting any symptoms. Chronic liver failure is often the result of cirrhosis, which is usually caused by long-term alcohol usage. Cirrhosis occurs when healthy liver tissue is replaced with scar tissue.

Causes of Hepatic Failure

Overdose is the most common cause of acute liver failure.

Acute liver failure may also be caused by:

  • viral infections, like hepatitis, including hepatitis A, B, and C
  • certain autoimmune diseases

Acute liver failure can also be genetic. You can get an abnormal gene from one or both of your parents. If you suffer from a genetic liver disease, you are more susceptible to liver failure.

Chronic liver failure is usually a result of alcohol-related liver disease. Usually, liver breaks down alcohol that has been consumed, but if the quantity of the drink is too much then liver is unable to break it. Then toxic chemicals present in alcohol trigger inflammation in liver, which can cause your liver to swell. This damage can lead to cirrhosis over time. If patient has hepatitis C, then he/she is at a greater risk of developing chronic liver failure or cirrhosis. The hepatitis C virus is spread through the blood. If the blood from an infected person enters anyone body, he/she can catch it. Needle sharing and using dirty needles during tattoos or piercings are ways that hepatitis C can spread.

Symptoms of Hepatic Failure

  • Jaundice
  • Weight loss
  • Nausea
  • Edema.
  • Diarrhea
  • Loss of appetite
  • Fatigue
  • Itching

These symptoms can also be related to other disorders, which can make liver failure hard to diagnose. Some people don’t have any signs until their liver failure has progressed to a deadly stage. Patient may feel drowsy or even slip into a coma by the time he/she reached that stage.

If patient suffers from alcohol-related liver disease, he may develop jaundice. Toxins can build up in your brain and cause sleeplessness, lack of concentration, and even decreased mental function. Patient may also experience an enlarged spleen, stomach bleeding, and kidney failure. Liver cancer can also develop.

Diagnosis and Treatment

There are several different blood screening tests that can be done to detect any abnormalities in the blood, including abnormalities that may imply liver failure. If patient is experiencing these problems, seek help from his doctor. If patient have a history of alcohol abuse or genetic abnormalities, be sure to let, doctor know. If patient is suffering from drug poisoning, such as from acetaminophen, your doctor may prescribe medication to reverse the effects. A biopsy is a common test used to determine liver damage. During a liver biopsy, a small piece of liver is extracted and examined in a lab. If it is caught early, some liver damage can be reversed. The damaged liver may repair itself or medication can help the repair process. If patient is overweight then patient is more risk to fatty liver disease. Treatment depends on the stage of the disease. A doctor can also take imaging tests of your liver to look for damage. If the damage is too severe, which can sometimes be the case with fast-acting acute liver failure, a liver transplant may be necessary.